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Conception doesn't always occur according to plan.

Fortunately for those experiencing infertility our fertility center provides effective and innovative treatments that make family-building a reality.

IUI SUMMARY

Intrauterine insemination, or IUI, is a safe procedure and often one of the first fertility treatments for couples who wish to become pregnant.

IUI relies on the natural ability of sperm to fertilize an egg in the fallopian tube. Studies show that IUI will not be as effective in cases where the male has an abnormal semen analysis. A semen analysis will confirm the health of the male partner's sperm.

From start to finish, an IUI procedure takes just a few minutes, requires no anesthesia, and is similar to a Pap smear. It is a simple, quick path for specially-prepared sperm to enter a woman's uterus via a small catheter. The timing of the procedure is based on a woman's ovulation for the highest possibility of pregnancy.

THE GOAL

The goal of this treatment is to increase the number of sperm that reach the fallopian tube and subsequently enhance the chance of fertilization. IUI essentially provides sperm with a "head-start" advantage, but still requires the sperm to reach and fertilize the egg on its own.

WHEN TO CHOOSE IUI

• Mild oligospermia/asthenospermia

• Males sexual dysfunction,genital malformation

• Female cervix related inferility

• Unexplained inferility

WHEN NOT TO CHOOSE IUI

Female bilateral salpingemphraxis or salpingectomy

OVULATION MEDICATIONS & IUI

Depending on your fertility diagnosis, it may be necessary to take certain ovulation induction medications,combined with your menstrual cycle and ultrasound monitoring of the ovulation,to determine the appropriate timing of IUI . By increasing egg production with medication, IUI can increase a woman's chance of conception.

Those with ovulation disorder like polycystic ovarian syndrome and unexplained infertility are among the populations who most benefit from the combination of fertility medication and IUI.

OVULATION MONITORING/INDUCTION

For female ovulates normally we will monitor the ovulation.For female with ovualtion disorders,to increase the rate of fertilization with IUI and pregnancy,ovulation induction medicine could be used at the beginning of the menstrual cycle.

OVULATION TIME

You will monitor and track your follicle growth together with our team.Combined with examinations like transvaginal ultrasonography,we will predict the ovulation date.Generally,in one or two days around the ovulation,the doctor will make a customized treatment plan according to your personal condition and then schedule the time for IUI.

SEMEN PREPARATION/SEMEN ANALSIS

As ovulation occurs, a semen sample from either a donor or the male partner will be prepared in our laboratory for insemination.

Once collected, the semen sample is then "washed" in the laboratory to concentrate the sperm and remove the seminal fluid (seminal fluid can cause severe cramping in the woman).

INSEMINATION

The IUI procedure itself is relatively simple and is performed once the semen sample is ready. From start to finish, the IUI procedure only takes several  minutes, and you may continue about your day after the procedure has concluded.

PREGNANCY TEST

After two weeks of normal activity, you will return for a blood test, which is more sensitive to pregnancy hormones after fertilization than a standard "at-home" pregnancy test.

For couples whose infertility persists despite conventional first-line treatments, in vitro fertilization (IVF) offers a logical next step.

With pregnancy rates up to five times that of intrauterine insemination, IVF is the most effective fertility treatment available today. It is the most common form of fertility treatment and is particularly helpful for women of advanced age, women with damaged fallopian tubes, female with endometriosis , male factor infertility, and unexplained infertility.

OUR IVF SUCCESS

Here at the Renji International VIP Department, we specialize in IVF. Renji Hospital has built a reputation as a respected source for this advanced reproductive technology and as a Tier 3A Hospital is proud to utilize the most advanced technology and equipment in the world. We offer a variety of modifications to the standard IVF process to help patients with specific disorders.

Our dedicated Reproductive Medical Center and IVF experts lead by our international director, Dr. Steven Lindheim, offer the experience, technologies, guidance, and support to help you achieve an IVF pregnancy in the shortest time possible.

Our ability to treat both routine and complicated cases is a testament to the Renji team that includes more than a 100 physicians, nurses, scientists, PhDs, embryologists, and lab technicians who together provide you with valuable insight, unique perspectives, and world-class care that maximizes your success.

IVF: SUMMARY

• During IVF, eggs are collected from a woman's ovaries through the vagina in an outpatient surgical procedure and fertilized by sperm in our lab

• If the male partner has an abnormal sperm, then fertilization can be achieved by injecting a single sperm into each egg in a process called Intra-Cytoplasmic Sperm Injection (ICSI)

• In the process of assisted reproduction,individualized ovarian stimulation program and medicine contronalled ovulation will be performed,inorder to obtain more eggs.This process takes about 2-4 weeks, culminating in multiple eggs being retrieved from a woman's ovaries and fertilized with sperm

• The fertilized eggs, now called embryos, are then implanted into the woman's uterus three to five days after fertilization - or may be frozen for use. Embryo transfer could be performed after rest and relaxation.

• The Ruiwen IVF team will work with you to determine an individualized and appropriate pathway to help you achieve your goals in creating or growing your family

IVF provides many people with the opportunity to attempt pregnancy in the face of one or more factors that may otherwise decrease their chances. Below you will find the most common reasons for women/couples to consider IVF treatment.

REASONS TO CHOOSE IVF

• Those who have been unsuccessful with simpler treatments including IUI

• Age-related infertility

• Low ovarian reserve

• Recurrent miscarriage

• Those who carry or have a family history of genetic defects

• Women with blocked or damaged fallopian tubes

• Unable to ovulate including polycystic ovary syndrome (PCOS)

• Endometriosis

• Men with poor sperm quality or quantity

• Unexplained infertility

At the Renji International VIP Department, the IVF process is characterized by a variety of different stages. They include:

INITIAL CONSULTATION

Your initial consultation, the very first step in the IVF process, is an opportunity for your Ruiwen IVF clinical team to learn more about your medical history and begin to design a customized IVF treatment plan that addresses your goals and maximizes your success. Once a comprehensive work-up that includes blood work to assess ovarian reserve, pelvic ultrasound, and a semen analysis have been completed, your care team will prepare you to begin your IVF cycle.

CONTROLLED OVARIAN HYPERSTIMULATION 

Normally, a woman produces one egg per month in her menstruation cycle.  Ovulation  induction medications send signal to the ovaries to promote the development of multiple follicles. This process of stimulation may continue for eight to twelve days,  in the meantime, your nursing team will monitor the ovarian status by ultrasound and monitor the hormone levels through blood tests to monitor the ovulation induction process. Once the follicles are mature in size, egg maturation is further induced by injection of HCG (human chorionic gonadotropin) and/or GnRHa (gonadotropin releasing hormone agonist).

EGG RETRIEVAL 

Approximately, thirty-six hours after the HCG/GnRHa injection, the eggs are removed from the woman's ovaries. To collect mature eggs from the woman's body, a physician at the Renji International VIP department performs a minor outpatient surgery under the guidance of transvaginal ultrasound, retrieving eggs through vaginal puncture. The surgery is a short 10 to 15-minute procedure performed at the state of art, Renji Reproductive Medical Center. An intravenous anesthesia is administered to ensure comfort. Most women are able to return home within an hour after the procedure. On the same day, your partner will provide a fresh semen sample to our lab. If you have obtained frozen donor sperm, we will ensure this sample has been received and tested prior to your retrieval. Following egg retrieval, you will begin progesterone to prepare for the embryos being transferred back to the uterusImplantation typically will occur three to five days later.

EMBRYO DEVELOPMENT

Our embryologists combine the eggs with sperm for fertilization within a few hours after insemination. Fertilized eggs, now called embryos, are kept in our incubators to develop further. If your embryologist thinks the chance of fertilization is low, the sperm may be directly injected into the egg. This process is called ICSI.

EMBRYO SELECTION

Our team of embryologists will regularly monitor your embryos to assure they are growing properly. Within five to six days, a normal embryo develops into many cells (>150) that are actively dividing. At this point, couples with a risk of passing on a genetic disorder to their child may consider undergoing preimplantation genetic testing (PGT). Renji utilizes the most advanced genetic testing in China. Our embryologists will assess embryo quality according to internationally harmonized standards. We will select embryos with best quality to increase your chances of successful and healthy conception.

EMBRYO TRANSFER

Three to five days after egg retrieval and fertilization, embryos are typically transferred into the woman's uterus. This procedure (similar to a Pap smear) occurs in the Renji procedure room using a catheter inserted through the cervix that takes less then few minutes to perform. Most women are able to resume regular activities the next day. If an embryo implants to the uterine lining and grows, pregnancy results. Any unused high quality embryos may be frozen to allow the option of future implantation.

POST-TRANSFER

To help assure the uterine lining is most receptive for the embryo to implant, you will continue progesterone therapy for two weeks after embryo transfer. A blood test for pregnancy is performed fourteen days after the embryo transfer. If pregnancy is confirmed, you will continue progesterone until your placenta produces enough hormones to support the pregnancy on its own. If a pregnancy cannot be confirmed, you may decide with your doctor to begin another cycle of IVF.

Many couples assume that infertility is solely a female issue, but actually affects both men and women equally worldwide. The reality is that just about 40% of all infertility cases stem from male-factor issues. Thus, male infertility testing is crucial in order to assure every couple's treatment plan is appropriate upon the start of care.

ABOUT OUR PROGRAM

The Ruiwen Male Infertility Program is an international VIP program with cutting-edge technologies, equipment and techniques combining the best of American and Chinese expertise and the resources that only a 3A academic hospital can provide.

The Ruiwen program identifies all causes of infertility. Our team has 50+ years of expertise and has successfully diagnosed tens of thousands of male infertility cases; moreover, the advantage of the Ruiwen international VIP department is that we have the time and expertise to develop customized and individual treatment plans that lead to successful outcomes.

DIAGNOSIS AND TESTING

Our experts and national level laboratory makes testing and analysis easier, faster and more accurate: the advantage of the Renji Reproductive hospital.

MALE INFERTILITY CAUSES

There may be very few or even no any obvious sign of male infertility. Therefore, we must seek the diagnosis and treatment from infertility experts, who will conduct a series of medical history collection and examination to find the cause and clear diagnosis, find a solution of the fertility as soon as possible . Common causes of male factor infertility include:

• Erectile dysfunction

• Ejaculation problems (no sperm or premature)

• Azoospermia: no sperm resulting from physical obstruction of the ducts in the testicles

• Chemotherapy from cancer treatment

• Hormone imbalances

• Genetic abnormalities

• Obesity

• Poor nutrition

• Stress

• Sexually transmitted diseases

• Smoking

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